Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/10/2025

Bupropion-Associated Hypertension

Monitoring and Contraindications

  • For patients taking naltrexone-bupropion ER for weight management, blood pressure and heart rate should be monitored periodically, especially in the first 12 weeks of treatment, as recommended by clinical guidelines 1, 2
  • Naltrexone-bupropion ER should be avoided in patients with uncontrolled hypertension, according to the American Gastroenterological Association 2