Equivalent Dose Conversion: Dulaglutide to Liraglutide
Direct Comparison Evidence
- The American College of Cardiology suggests that when switching from dulaglutide to liraglutide, the titration requirement for liraglutide may reduce acute GI symptoms compared to direct initiation 1
Practical Conversion Approach
- The American College of Cardiology recommends a target dose of liraglutide 1.8 mg daily when switching from dulaglutide 1.5 mg weekly, with a titration schedule starting at 0.6 mg daily for 1 week, then increasing to 1.2 mg daily for at least 1 week, then advancing to 1.8 mg daily 1
Important Caveats
- The American College of Cardiology and Kidney International indicate that cardiovascular and renal benefits are established for both dulaglutide and liraglutide in patients with type 2 diabetes and chronic kidney disease, with no dose adjustment required for either medication across all stages of CKD 1, 2