Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 10/21/2025

Venlafaxine-Induced Hyponatremia

Patient Risk Factors

  • The European Society of Cardiology warns that concomitant diuretic use, especially thiazides, increases the risk of hyponatremia in patients taking venlafaxine 1

Management and Treatment

  • The American Academy of Neurology recommends that if discontinuation of venlafaxine is necessary, it should be tapered slowly to avoid discontinuation syndrome, as suggested by Praxis Medical Insights 2