Amoxicillin Safety in Patients with Chronic Kidney Disease

Dosing Considerations

• The American College of Physicians and other guideline societies recommend that amoxicillin be administered after dialysis sessions to prevent premature removal and ensure adequate dosing 1

Alternative Therapies

• For penicillin-allergic patients with CKD requiring prophylaxis, the American Dental Association recommends clindamycin 600 mg orally, which does not require dose adjustment in CKD and avoids nephrotoxicity concerns 2