Adverse Effects of Duloxetine

Common Adverse Effects

The American College of Clinical Pharmacology notes that most common side effects of duloxetine include nausea, dry mouth, headache, constipation, dizziness, decreased appetite, somnolence, and fatigue 1

The National Institute of Mental Health suggests that drug interactions, particularly with duloxetine as a moderate CYP2D6 inhibitor, could increase levels of other medications that cause dysarthria 2
The American Academy of Neurology recommends considering concurrent medications such as benzodiazepines, antipsychotics, or other CNS depressants as well-documented causes of dysarthria 3, 4
The American Heart Association advises that new-onset dysarthria warrants evaluation for underlying neurological conditions such as stroke, neurodegenerative disease, or other structural brain pathology 4
The International Parkinson and Movement Disorder Society notes that functional neurological disorder can cause speech disturbances, particularly in patients with anxiety or depression 4

The American Medical Association recommends not attributing slurred speech to duloxetine without thoroughly investigating other causes, as this is not a recognized adverse effect of the medication 1
The American Academy of Pediatrics suggests reviewing the complete medication list for drugs known to cause dysarthria, particularly sedatives, antipsychotics, and anticholinergics 3, 5
The American Stroke Association advises performing a neurological examination to rule out serious causes such as stroke, particularly if onset is acute 4