Discontinuing Viloxazine

Key Discontinuation Principles

• The American Academy of Child and Adolescent Psychiatry suggests that viloxazine can be stopped abruptly if clinically indicated, though a gradual approach may still be prudent for monitoring purposes 1
• The medication can be discontinued if the patient has not achieved adequate symptom improvement after an appropriate trial period, according to the American Academy of Child and Adolescent Psychiatry 1

Important Safety Considerations

• The American Academy of Child and Adolescent Psychiatry recommends monitoring for return of ADHD symptoms during and after discontinuation, as well as extended monitoring as symptom recurrence can occur weeks after the last dose 1
• Monitoring for cardiovascular parameters, such as blood pressure and pulse, is necessary during discontinuation, as viloxazine can cause increases in these measures, as noted by Praxis Medical Insights 2
• It is essential to watch for mood changes or behavioral symptoms, particularly in younger patients, given the suicidal thinking risk, according to Praxis Medical Insights 2

Post-Discontinuation Planning

• The American Academy of Child and Adolescent Psychiatry recommends developing a monitoring plan to assess whether ADHD symptoms return after stopping viloxazine 1
• Praxis Medical Insights suggests considering alternative ADHD treatments if discontinuation is due to lack of efficacy rather than adverse effects 3
• Documenting the reason for discontinuation and response can help guide future treatment decisions, as recommended by the American Academy of Child and Adolescent Psychiatry 1