Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/3/2025

Treatment of Status Epilepticus

Refractory Status Epilepticus Management

  • For refractory status epilepticus, other agents like valproate (30 mg/kg IV), levetiracetam (30 mg/kg IV), or phenobarbital are currently more established options, according to the Annals of Emergency Medicine 1
  • The American College of Emergency Physicians recommends considering alternative treatments for refractory status epilepticus, with valproate, levetiracetam, and phenobarbital being viable options 1