Beta Blocker-Associated Cold Extremities

Mechanism and Treatment Considerations

• Beta-1 selective agents (such as metoprolol, atenolol, bisoprolol) cause fewer peripheral vascular effects, according to the European Heart Journal 1
• Dose reduction may help alleviate symptoms while maintaining therapeutic benefits 2
• Elderly patients may be more susceptible to peripheral vascular effects of beta blockers 2
• Abrupt discontinuation of beta blockers should be avoided as it can lead to clinical deterioration, as reported in Circulation 3