Contraindications for Zavzpret (Zavegepant)

Key Safety Profile

Zavegepant can be safely used in patients with ischemic heart disease, stroke history, peripheral vascular disease, and uncontrolled hypertension, as it does not cause vasoconstriction, according to the American Gastroenterological Association 1
The American College of Gastroenterology recommends zavegepant as a safe option for acute migraine treatment in patients with cardiovascular risk factors who cannot use triptans, due to its lack of cardiovascular contraindications 1

The American Diabetes Association suggests that standard precautions for pregnancy should apply when using zavegepant, as with most acute migraine medications, although comprehensive data on pregnancy category is limited 2
The available evidence, as noted by the American Gastroenterological Association, does not provide specific pregnancy category information for zavegepant, unlike the detailed contraindication data available for triptans and other migraine medications 1, 2