Nystatin Treatment for Oral Candidiasis

Dosing and Administration

Nystatin oral suspension should be administered as 100,000 units (1 mL) three times daily, with treatment typically continuing for 7-10 days, and at least 48 hours after symptoms have resolved to prevent recurrence 1, 2

Nystatin works by decreasing the burden of Candida in the oral cavity by direct contact with the yeast, and has minimal systemic absorption, making it a safe option for children 1

For younger children who cannot swish and spit, the suspension can be applied directly to affected areas using a clean finger or cotton swab, and complete the full course of treatment even if symptoms resolve earlier to prevent recurrence 2
Inadequate duration of therapy is a common reason for treatment failure; ensure completion of the full course, and concurrent use of pacifiers or bottles in younger children can lead to reinfection; these items should be sterilized regularly during treatment 2
If the infection is severe or recurrent, consider evaluation for underlying conditions that may predispose to candidiasis 2