Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/31/2025

Management of Parkinson's Disease

Medication Considerations

  • Cholinesterase inhibitors like rivastigmine may help alleviate psychosis in Parkinson's disease patients with cognitive decline, according to the American Academy of Sleep Medicine 1
  • The American Society of Clinical Oncology recommends avoiding all typical antipsychotics, including prochlorperazine, haloperidol, and chlorpromazine, in Parkinson's disease patients 2

Treatment Approach

  • For patients with psychosis, rivastigmine may be considered, especially those with concurrent cognitive decline, as suggested by the American Academy of Sleep Medicine 1

REFERENCES

1

management of rem sleep behavior disorder: an american academy of sleep medicine clinical practice guideline. [LINK]

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2023