Management of Estrogen‑Induced Irregular and Heavy Bleeding in Perimenopausal Women with an Intact Uterus

Pathophysiology of Unopposed Estrogen

Hormone‑Therapy Regimens that Protect the Endometrium

Diagnostic Evaluation Before Initiating Therapy

Recommended Estrogen‑Progestogen Combination for Vasomotor Symptoms or Premature Menopause

Monitoring and Management of Persistent Bleeding

Safety Pitfalls to Avoid

Evidence Strength