Treatment of Invasive Candida Infections

Surgical Management

Source control through appropriate drainage is strongly recommended for all forms of invasive Candida infections, including Candida parotitis with abscess formation, as recommended by the Infectious Diseases Society of America 1, 2

Echinocandins, such as caspofungin, micafungin, or anidulafungin, are alternative antifungal options for fluconazole-resistant species, with dosing regimens including a 70-mg loading dose of caspofungin, then 50 mg daily, or 100 mg daily of micafungin, as recommended by the Infectious Diseases Society of America 1, 3
Amphotericin B deoxycholate, itraconazole solution, and posaconazole suspension are additional alternative antifungal options, with dosing regimens including 0.3-0.7 mg/kg daily of amphotericin B deoxycholate, 200 mg once daily of itraconazole solution, and 400 mg twice daily for 3 days then 400 mg daily of posaconazole suspension, as recommended by the Infectious Diseases Society of America 4

Treatment duration should be determined by clinical response and adequacy of source control, as recommended by the Infectious Diseases Society of America 1
Disinfection of dentures in addition to antifungal therapy is recommended to prevent reinfection in patients with dentures, as recommended by the Infectious Diseases Society of America 2