Haloperidol Use in Patients with Chronic Liver Disease and Psychosis

Safety Profile and Precautions

• The American Academy of Family Physicians recommends monitoring for extrapyramidal symptoms, which are common with haloperidol and may require dose reduction, in patients with chronic liver disease and psychosis 1
• If extrapyramidal symptoms occur, the American Academy of Family Physicians suggests decreasing the dose or considering switching to another agent, with a strength of evidence based on clinical experience 1
• The American Academy of Family Physicians advises avoiding the use of anticholinergic agents like benztropine or trihexyphenidyl to manage extrapyramidal symptoms in patients with liver disease, due to potential increased risk of adverse effects 1