Metoclopramide Usage and Precautions

Indications and Usage

• The National Comprehensive Cancer Network recommends metoclopramide for the management of opioid-induced nausea as an antiemetic agent for persistent nausea related to opioid therapy 1

Contraindications

• The FDA warns against the use of metoclopramide in patients with a history of seizure disorders, and it is contraindicated in patients with GI bleeding or obstruction, and pheochromocytoma, as stated by Praxis Medical Insights 2

Monitoring and Alternative Medications

• Praxis Medical Insights recommends regular neurological monitoring for signs of extrapyramidal symptoms, especially with long-term use of metoclopramide, and suggests alternative medications such as domperidone, erythromycin, or azithromycin, and prucalopride for certain conditions 3