Microneedling with Autologous Platelet Concentrates

Primary Topical Options

The American Academy of Dermatology recommends autologous platelet concentrates, such as Platelet-Rich Fibrin (PRF), as the most effective topical adjunct for microneedling, with PRF demonstrating superior outcomes to Platelet-Rich Plasma (PRP) for acne scars and skin rejuvenation 1, 2
Application timing is critical, with autologous platelet concentrates (APCs) applied to the skin before microneedling to allow the needling effect to push growth factors into the dermis, as recommended by the American Academy of Dermatology 1, 2
The treatment protocol for microneedling with APCs typically consists of 3 sessions spaced 1 month apart, then maintenance every 6 months, according to the American Academy of Dermatology 1, 2
The American Academy of Dermatology suggests ensuring skin is well lubricated with APCs during the procedure to avoid dry tugging sensation 6, 5

The American Academy of Dermatology advises against applying topical antibiotics, such as clindamycin and erythromycin, during active microneedling procedures 7
The American Academy of Dermatology recommends discontinuing topical retinoids, such as tretinoin, adapalene, and tazarotene, before microneedling to avoid excessive irritation 7, 8

The American Academy of Dermatology suggests using compounded topical anesthesia for at least 30 minutes prior to the procedure 6, 5

The American Academy of Dermatology advises patients to avoid sunlight and heavily scented facial products for 24 hours post-procedure 6, 5
The expected downtime after microneedling is typically 24-48 hours, according to the American Academy of Dermatology 6

For acne scars, microneedling combined with APCs shows higher odds of achieving notable/complete clinical improvement versus microneedling alone, with 85.4% improvement rates reported, as recommended by the American Academy of Dermatology 1, 2, 4
For skin rejuvenation, APCs work through extracellular matrix remodeling, increased matrix metalloproteinase expression, fibroblast proliferation, and collagen synthesis stimulation, according to the American Academy of Dermatology 3, 4