Transdermal Estrogen Patch Application Guidelines

Dosing Schedule Guidelines

• The American College of Physicians recommends that transdermal estradiol patches releasing 100 mcg/24 hours should be changed according to the specific instructions provided for each brand, which is typically either twice weekly or weekly 1
• For adult women requiring hormone replacement therapy, the recommended maintenance dose range is 100-200 mcg/day of transdermal estradiol 2

Clinical Considerations

• The American College of Obstetricians and Gynecologists recommends that when using transdermal estradiol patches in women with an intact uterus, progesterone should be added for endometrial protection 3
• The recommended progesterone regimen is 200 mg of oral or vaginal micronized progesterone daily for 12-14 days every 28 days in a sequential regimen 3