Raising Secretory IgA Levels through Targeted Interventions

Addressing Underlying Conditions and Clinical Considerations

• The American Academy of Allergy, Asthma, and Immunology recommends considering immunoglobulin replacement therapy in rare cases of severe IgA deficiency with recurrent infections that don't respond to other interventions 1
• The American Gastroenterological Association suggests evaluating for celiac disease in patients with unexplained IgA deficiency, as there's an association between these conditions 2
• The American Academy of Allergy, Asthma, and Immunology advises checking for medication-induced IgA deficiency from drugs such as phenytoin, carbamazepine, valproic acid, sulfasalazine, gold, penicillamine, hydroxychloroquine, and NSAIDs 1