Gastric Mucosal Barrier Protection

Components of the Gastric Mucosal Barrier

• Brunner's glands, located in the duodenum, secrete bicarbonate-rich mucus to neutralize gastric acid entering the duodenum, according to the American Gastroenterological Association 1
• The secretion of bicarbonate-rich mucus by Brunner's glands helps to deal with gastric pH as it enters the duodenum, as recommended by the American Gastroenterological Association 1
• Brunner's glands produce PG II (pepsinogen II) but not PG I, contributing to duodenal protection, as stated by the American Gastroenterological Association 1