Methocarbamol and Cyclobenzaprine Conversion Guidelines

Special Considerations

• The American College of Physicians and other guideline societies recommend using cyclobenzaprine and methocarbamol with caution in elderly patients, as cyclobenzaprine has significant anticholinergic effects that may be more pronounced in this population 1
• Both medications should be held on the day of surgery, and if time permits, consider tapering cyclobenzaprine over 2-3 weeks to prevent withdrawal symptoms 1
• The Mayo Clinic recommends that both medications should be used with caution in patients undergoing surgery, and methocarbamol may cause drowsiness, dizziness, and cardiovascular effects including bradycardia and hypotension 2

Potential Adverse Effects

• Cyclobenzaprine has anticholinergic effects including hallucinations, confusion, drowsiness, constipation, urinary retention, and dry mouth, as reported by the Mayo Clinic and Praxis Medical Insights 1, 2