Higher-Dose Trazodone Guidelines

Treatment-Resistant Depression

• The American Academy of Family Physicians suggests considering doses in the 300-400 mg/day range for patients who have failed two or more antidepressants of different mechanisms 1, 2

Elderly Patients with Severe Depression

• The American Geriatrics Society recommends starting with a dose of 25 mg daily with gradual titration by 25 mg increments every 5-7 days for elderly patients with severe depression 3
• The American Geriatrics Society advises that trazodone may be appropriate for severe agitation in dementia or treatment-resistant depression when other options have failed, with close surveillance for orthostatic hypotension, falls, and cardiac effects 3