Insulin Resistance Management with Semaglutide

Mechanism of Action and Effects on Insulin Resistance

• Semaglutide, a glucagon-like peptide-1 receptor agonist, improves glycemic control in type 2 diabetes through multiple mechanisms, as recommended by the American Diabetes Association 1

Cardiovascular and Renal Benefits Related to Insulin Resistance

• The American College of Cardiology notes that semaglutide reduces the risk of cardiovascular death, nonfatal MI, or nonfatal stroke by 26% compared to placebo, as seen in the SUSTAIN-6 trial 2
• The American Heart Association suggests that semaglutide may have benefits in heart failure with preserved ejection fraction (HFpEF), with improvements in symptoms and exercise function 3