Trastuzumab Pharmacokinetics and Dosage

Introduction to Trastuzumab Regimens

• The American Society of Clinical Oncology and the National Comprehensive Cancer Network recommend a weekly dosing regimen of trastuzumab, with a loading dose of 4 mg/kg IV followed by 2 mg/kg IV weekly, or a dosing regimen every 3 weeks, with a loading dose of 8 mg/kg IV followed by 6 mg/kg IV every 3 weeks, for patients with HER2-positive breast cancer 1, 2, 3

Monitoring and Special Considerations

• The National Comprehensive Cancer Network recommends cardiac monitoring for patients receiving trastuzumab, at the start of treatment, and at 3, 6, and 9 months of treatment, due to the potential risk of cardiotoxicity 2, 4