Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/28/2025

Consequences of Not Wearing CPAP for Obstructive Sleep Apnea

Immediate Consequences (Within Days)

  • Rapid return of apneic events can occur when CPAP therapy is stopped, even after just one night, according to the American Thoracic Society 1
  • Return of daytime sleepiness can happen within as little as one night off CPAP therapy, as reported by the American Academy of Sleep Medicine 1
  • Impaired driving ability, comparable to being over the legal blood alcohol limit, can occur when CPAP therapy is discontinued, as noted by the American College of Chest Physicians 2
  • Increased blood pressure elevations can happen rapidly after CPAP withdrawal, as observed by the American Heart Association 1
  • Increased heart rate and cardiovascular stress begin immediately when CPAP therapy is discontinued, according to the American College of Cardiology 1

Neurocognitive Consequences

  • Excessive daytime sleepiness can affect daily functioning and quality of life, as reported by the American Academy of Sleep Medicine 2
  • Increased risk of motor vehicle accidents can occur in OSA patients without CPAP treatment, as noted by the National Highway Traffic Safety Administration 2
  • Cognitive impairment, including memory, attention, and executive function deterioration, can happen without adequate treatment, according to the American Neurological Association 3

Cardiovascular Consequences

  • Hypertension can develop and be poorly controlled in untreated OSA patients, as observed by the American Heart Association 2
  • Myocardial infarction risk can increase in untreated patients, as reported by the American College of Cardiology 2
  • Stroke risk can be higher in untreated OSA patients, according to the American Stroke Association 2
  • Cardiac arrhythmias, including atrial fibrillation, bradycardia/tachycardia, heart block, and sinus pauses, can occur in untreated OSA patients, as noted by the American College of Cardiology 2
  • Pulmonary hypertension can develop in untreated OSA patients, as observed by the American Thoracic Society 2
  • Increased mortality risk, ranging from 10-20 years, can occur in untreated moderate-to-severe OSA patients, as reported by the American College of Chest Physicians 2

Metabolic Consequences

  • Poor glycemic control can worsen in untreated OSA patients with diabetes, according to the American Diabetes Association 3

Important Clinical Considerations

  • Early intervention for non-adherence, within 7-90 days, may improve long-term adherence, as recommended by the American Academy of Sleep Medicine 4
  • Long-term monitoring is essential for optimal outcomes in OSA patients, as noted by the American Thoracic Society 5

Common Pitfalls in CPAP Management

  • Failing to address early adherence issues, such as mask fit, pressure settings, or side effects, can lead to treatment abandonment, as reported by the American College of Chest Physicians 4
  • Underestimating cardiovascular impact can occur even in asymptomatic patients with minimal sleepiness, according to the American College of Cardiology 2
  • Discontinuing monitoring can lead to suboptimal outcomes, as noted by the American Thoracic Society 5