Medication-Related Weight Changes

Antidepressants and Weight Gain

• Among antidepressants, paroxetine has the highest risk of weight gain within the SSRI class, while fluoxetine and sertraline are typically associated with initial weight loss followed by weight neutrality with long-term use 1
• Bupropion is the only antidepressant consistently shown to promote weight loss 2

Beta-Blockers and Weight Gain

• Beta-blockers, particularly non-selective ones, can promote weight gain by decreasing metabolic rate and affecting energy metabolism 2