Venlafaxine Dosing and Safety Considerations for Anxiety

Formulation and Dosing

• Extended-release (ER) formulation allows for once-daily dosing due to longer elimination half-life 1
• Blood pressure monitoring is essential, particularly when exceeding 150 mg/day, as venlafaxine can cause dose-dependent increases in blood pressure 1, 2

Discontinuation and Special Considerations

• Abrupt discontinuation should be avoided; tapering over 10-14 days is recommended to prevent withdrawal symptoms 1, 2
• Venlafaxine is not recommended for nightmares associated with PTSD based on clinical evidence from the American Academy of Sleep Medicine 3