DHEA Measurement and Interpretation

Clinical Considerations

• For transgender and gender-diverse individuals on gender-affirming hormone therapy (GAHT), laboratory values should be interpreted in the context of their GAHT regimen, as recommended by the American Cancer Society, with consideration of the individual's affirmed gender after more than 1 year of GAHT 1, 2

Measurement Methods

• Direct immunoassays for DHEA measurement have a sensitivity of 0.67 (95% CI: 0.48-0.82) and specificity of 0.70 (95% CI: 0.46-0.86), according to the European Society of Human Reproduction and Embryology 3
• LC-MS/MS methods for DHEA measurement have a sensitivity of 0.82 (95% CI: 0.59-0.93) and specificity of 0.57 (95% CI: 0.25-0.84), as reported by the European Society of Human Reproduction and Embryology 3