Adverse Effects of Pazopanib

Common Adverse Reactions

• The most frequently reported adverse effects of pazopanib include diarrhea, hypertension, hair color changes, nausea, anorexia, vomiting, fatigue, and weakness, as reported by the National Comprehensive Cancer Network 1, 2, 3

Critical Grade 3/4 Toxicities Requiring Monitoring

• Hepatotoxicity is a notable severe toxicity of pazopanib, with elevated liver enzymes, mandating liver function monitoring before and during treatment, according to the National Comprehensive Cancer Network 1, 3, 4
• Cardiac rhythm irregularities have been associated with pazopanib use, as reported by the National Comprehensive Cancer Network 1, 4