Celecoxib Elimination and Perioperative Management

Pharmacokinetics and Elimination

• Celecoxib has a medium half-life among NSAIDs, longer than ibuprofen but shorter than meloxicam, with a half-life of 11 hours 1
• The American College of Chest Physicians recommends stopping celecoxib 2-3 days before elective surgery to allow adequate drug clearance, due to its reversible antiplatelet effects 1

Perioperative Considerations

• Platelet function returns to normal once celecoxib is eliminated, allowing for safer surgical procedures 1