First‑Line Therapy Recommendations for Montelukast Use

Allergic Rhinitis

• The FDA recommends reserving montelukast for patients with allergic rhinitis only after inadequate response or intolerance to intranasal corticosteroids, which should be used as the first‑line therapy. [1][2]

Asthma Management

• For persistent asthma, inhaled corticosteroids are preferred over leukotriene receptor antagonists such as montelukast as the primary maintenance treatment. [3][4]2