Domperidone Contraindications and Cardiac Safety

Introduction to Contraindications

• Domperidone is contraindicated in patients with gastrointestinal obstruction, QT prolongation, electrolyte abnormalities, and concurrent use of QT-prolonging medications due to significant risk of cardiac arrhythmias and sudden cardiac death 1, 2

Cardiac Safety Monitoring

• Regular QTc monitoring is recommended for patients on long-term therapy 1, 2

Special Populations and Considerations

• Diabetic patients with gastroparesis may use domperidone, but cardiac risks must be carefully weighed against benefits 3, 4