Hydroxyzine Dosage and Administration

Special Populations

• The American College of Physicians recommends reducing the dose of hydroxyzine by half in elderly patients due to age-related decline in renal function and increased sensitivity to central nervous system effects 1
• Elderly patients experience higher rates of CNS and gastrointestinal symptoms at standard doses, according to the Centers for Disease Control and Prevention 2

Contraindications and Precautions

• The American Academy of Family Physicians advises avoiding hydroxyzine in early pregnancy, especially in the first trimester 1
• The National Institute of Diabetes and Digestive and Kidney Diseases recommends avoiding hydroxyzine in severe liver disease due to the risk of accumulation 1
• The American College of Physicians recommends dose reduction in patients with renal impairment 1