Meropenem Dosing in Pediatric Patients with Multidrug-Resistant Infections

Special Populations and Considerations

• For multidrug-resistant tuberculosis in children, the American Thoracic Society recommends meropenem dosed at 20-40 mg/kg per dose three times daily, typically combined with clavulanate, with frequency reduction in renal dysfunction 1
• For carbapenem-resistant Enterobacterales or extensively drug-resistant organisms in pediatric patients, the Infectious Diseases Society of America suggests dosing follows standard recommendations, though combination therapy is often required, with a moderate strength of evidence 2, 3