Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/18/2025

Management of Antidepressants in Patients with Glaucoma

Monitoring and Clinical Approach

  • All patients with glaucoma who are prescribed antidepressants should remain under rigorous supervision of an ophthalmologist with regular monitoring of intraocular pressure 1
  • Target intraocular pressure should be maintained at approximately 20% lower than baseline measurements to prevent glaucomatous damage 2
  • Before initiating antidepressant therapy in glaucoma patients, a baseline ophthalmologic examination is recommended to document optic nerve status and visual field 3
  • For patients with severe or unstable glaucoma, consultation between psychiatry and ophthalmology is advisable before initiating antidepressant therapy 1