Vaginal Progesterone Formulations and Clinical Guideline Recommendations

Available Formulations and Efficacy

• The American College of Obstetricians and Gynecologists recommends using either 90-mg vaginal progesterone gel or 200-mg micronized progesterone suppository daily for prevention of preterm birth in women with short cervix (≤20 mm) from diagnosis until 36 weeks 1, 2, 4
• The use of vaginal progesterone for short cervix indication is currently off-label and requires patient counseling, as stated by the American Journal of Obstetrics and Gynecology 3
• Both formulations (90 mg gel and 200 mg capsules) have been studied in randomized trials with demonstrated efficacy for preventing preterm birth in women with short cervix 1, 2, 3

Clinical Guideline Recommendations for Prevention of Preterm Birth

• For women with short cervix (≤20 mm), the recommended treatment is either 90-mg vaginal progesterone gel or 200-mg micronized progesterone suppository daily from diagnosis until 36 weeks, according to the American College of Obstetricians and Gynecologists 1, 2, 4