Treatment of Depression with Agomelatine

Efficacy and Safety Considerations

• The American College of Physicians recommends choosing antidepressants based on side effect profiles, cost, and patient preferences 1
• Available evidence does not support clinically significant differences in efficacy between SSRIs, SNRIs, and other second-generation antidepressants for the treatment of acute major depressive disorder 1, 2

Side Effect Profiles

• Common side effects of second-generation antidepressants include constipation, diarrhea, dizziness, headache, insomnia, nausea, sexual side effects, and somnolence 2, 3