Cefuroxime Dosing Guidelines

Clinical Dosing Context

• Surgical prophylaxis typically uses 1.5g IV as a slow infusion, with re-injection of 0.75g if the procedure exceeds 2 hours, as recommended by the Anaesthesia guideline society 1
• The American Society of Anaesthesiologists recommends surgical prophylaxis with 1.5g IV cefuroxime, with re-injection of 0.75g if the procedure exceeds 2 hours, according to Praxis Medical Insights 2
• However, a more recent guideline from a non-Praxis source is not available, but Praxis Medical Insights also recommends this dosing regimen in 2026 3