Pregabalin-Induced Constipation Mechanism and Management

Physiological Mechanisms

• Pregabalin affects calcium channels in the enteric nervous system, which may reduce peristaltic activity similar to how opioids affect the gastrointestinal tract 1
• Pre-existing gastrointestinal motility disorders are a risk factor for pregabalin-induced constipation 1

Management Approaches

• For persistent constipation, osmotic laxatives such as polyethylene glycol (PEG) are recommended as first-line treatment 2
• Stimulant laxatives like bisacodyl or senna may be needed for more severe cases 2
• Ensuring adequate hydration and physical activity when appropriate 3
• Dietary interventions with adequate fiber intake may be helpful for patients with sufficient fluid intake 3