Vaxelis Vaccination Guidelines

Minimum Interval Requirements

The minimum interval between any two doses of Vaxelis is 4 weeks, as recommended by the Centers for Disease Control and Prevention 1, 2
The minimum age for dose 2 of Vaxelis is 10 weeks, and for dose 3 is 24 weeks (6 months), according to the Centers for Disease Control and Prevention 1, 2

The third dose of Vaxelis should not be given before 24 weeks of age due to the hepatitis B component requiring adequate immune maturation, as stated by the Centers for Disease Control and Prevention 1, 2
If the third dose is inadvertently given before 24 weeks of age, an additional dose of hepatitis B vaccine must be given at age ≥24 weeks to complete the hepatitis B series, as recommended by the Centers for Disease Control and Prevention 1, 2

There is no need to restart a vaccine series regardless of the time that has elapsed between doses, according to the American Academy of Pediatrics 3
Doses should not be administered at intervals less than the minimum intervals, as stated by the Centers for Disease Control and Prevention 1, 4

Vaxelis is only indicated for the primary 3-dose series at 2, 4, and 6 months and should not be used for booster doses, as recommended by the Centers for Disease Control and Prevention 1, 2
Vaxelis requires a 3-dose primary series for the Hib component, unlike some monovalent PRP-OMP Hib vaccines that only require 2 primary doses, according to the Centers for Disease Control and Prevention 1, 2
The maximum age for any dose of Vaxelis is 4 years, 364 days (do not administer on or after the fifth birthday), as stated by the Centers for Disease Control and Prevention 1, 2