Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/29/2025

Appropriate Use of Vyvanse in ADHD Diagnosis

Diagnostic Requirements and Approved Indications

  • Medication is not appropriate for children whose symptoms do not meet DSM-IV criteria for diagnosis of ADHD, as stated by the American Academy of Pediatrics 1
  • Lisdexamfetamine and atomoxetine are approved as first-line therapies in the United States, but as second-line therapies in many European countries, according to regulatory guidelines 2

Regulatory Framework

  • The approval status of lisdexamfetamine varies by country and requires consideration of local regulations, but universally requires an established diagnosis within the approved indications, as outlined in Pharmacology and Therapeutics guidelines 2