Vitamin B6 for Akathisia: Safety Considerations

Critical Safety Considerations

• Prolonged use of vitamin B6 doses ≥300 mg/day can cause sensory neuropathy, and even 100 mg/day long-term has been associated with neurological complications, according to Clinical Nutrition guidelines 1
• The standard supplementation dose of 25-50 mg/day used for isoniazid-induced neuropathy prevention should not be confused with the therapeutic doses used for akathisia, as stated by Clinical Infectious Diseases guidelines 2