Testosterone Replacement Therapy for Women with Specific Indications

Indications and Contraindications

Testosterone therapy may be considered for women with premature ovarian insufficiency (POI) due to medical treatments like chemotherapy or radiation, as stated by the guideline society Praxis Medical Insights 1
For women with an intact uterus requiring hormone therapy, guidelines typically recommend estrogen plus progestin rather than estrogen plus androgen combinations, according to Praxis Medical Insights 2
Testosterone should not be used for primary prevention of chronic conditions, as advised by Praxis Medical Insights 2, 1
Women with hormone-sensitive cancers should avoid systemic hormone therapy, as recommended by Praxis Medical Insights 1

For women with premature ovarian insufficiency (POI), 17β-estradiol (17βE) is the preferred estrogen component of HRT, which can be combined with appropriate progestins, as stated in Blood Reviews 3, 4
In cancer survivors with POI, testosterone therapy decisions should be made in consultation with specialists, according to Praxis Medical Insights 5
Short-term studies (up to 2 years) have shown that testosterone therapy at appropriate doses does not increase risk of hepatotoxicity or endometrial hyperplasia, as reported in Blood Reviews 3