Dosing of Strattera (Atomoxetine) When Used Alongside Vyvanse (Lisdexamfetamine) for ADHD

Atomoxetine Dosing Guidelines

• The American Academy of Pediatrics recommends an initial dose of atomoxetine at 40 mg orally once daily, with titration every 7-14 days to 60 mg then 80 mg daily, and a maximum dose of either 1.4 mg/kg/day or 100 mg/day (whichever is less) 1, 2
• The initial dose and titration schedule for atomoxetine is 40 mg orally once daily, adjusting the dose every 7-14 days, typically to 60 mg then 80 mg daily 1
• The maximum recommended dose for atomoxetine is the lesser of 1.4 mg/kg/day or 100 mg/day 1

Lisdexamfetamine Dosing (For Reference)

• The American Academy of Pediatrics recommends an initial dose of lisdexamfetamine at 20-30 mg orally once daily in the morning, with a titration schedule of increasing by 10 mg weekly, and a maximum dose of 70 mg daily 3, 4

Monitoring Parameters

• The American Academy of Pediatrics recommends monitoring for signs of irritability, insomnia, or changes in mood when using lisdexamfetamine 4

Pharmacological Rationale

• Lisdexamfetamine is a prodrug that converts to dextroamphetamine after ingestion, according to the American Academy of Pediatrics 5