Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/27/2025

Hyperbaric Oxygen Therapy for Athletic Performance

Current Guidelines and Recommendations

  • The International Working Group on the Diabetic Foot (IWGDF) and the Infectious Diseases Society of America (IDSA) guidelines suggest against using HBO therapy as an adjunctive treatment due to low certainty of evidence, high costs, and limited availability 1, 2
  • HBO therapy is recognized for specific medical conditions but not for athletic performance enhancement, according to guidelines from the IWGDF/IDSA 1, 2
  • The primary indications for HBO therapy are medical conditions such as necrotizing soft tissue infections, compromised skin grafts, and non-healing wounds, not for performance enhancement, as stated by the World Journal of Emergency Surgery 3, 4

Physiological Effects and Mechanisms

  • Theoretical benefits of HBO therapy include increased oxygen delivery to tissues, improved leukocyte function, and enhanced mitochondrial function, as reported by the World Journal of Emergency Surgery and Sports Medicine 4, 5

Specific Considerations for Athletes

Sex-Based Differences

  • Limited research exists on sex-specific responses to HBO therapy for athletic performance, with some evidence suggesting women may have different physiological responses to hypoxia compared to men, as reported by Sports Medicine 5, 6
  • Women may have lower sensitivity to hypoxia than men, which could affect responses to HBO therapy, according to Sports Medicine 6

Practical Considerations

  • HBO therapy is expensive, has limited availability, and requires specialized equipment, making the cost-benefit ratio for athletic performance enhancement unjustifiable, as stated by the Diabetes/Metabolism Research and Reviews 1, 2

Potential Risks and Limitations

Safety Concerns

  • Side effects of HBO therapy may include transient myopia, barotrauma of the middle ear or sinuses, and claustrophobia, as reported by the journal Stroke 8
  • HBO therapy can occasionally induce seizures, according to the journal Stroke 8

Alternative Approaches for Performance Enhancement

  • Traditional altitude/hypoxic training strategies like "Live High-Train Low" have more established evidence for improving endurance performance, as reported by Sports Medicine 5, 7
  • Proper periodization and individualization of training are critical aspects with stronger evidence for performance enhancement, according to Sports Medicine 5
  • Focus on evidence-based recovery methods, nutrition, and conventional training adaptations rather than HBO therapy, as recommended by Sports Medicine 5, 7