Vitamin K Supplementation and Coronary Artery Calcium Scores

Current Evidence on Vitamin K and Vascular Calcification

• The KDIGO Controversies Conference reported mixed results from clinical trials examining vitamin K supplementation for vascular calcification in chronic kidney disease (CKD) patients 1
• The KDIGO guidelines suggest that vitamin K supplementation may have potential benefits for reducing vascular calcification progression in CKD patients, especially those on dialysis 1

Special Considerations for Specific Populations

• The KDOQI Clinical Practice Guidelines recommend that patients receiving anticoagulant medicines that inhibit vitamin K activity (e.g., warfarin) should not receive vitamin K supplements 2

Current Recommendations

• The New England Journal of Medicine clinical practice guidelines do not address vitamin K supplementation for vascular calcification, highlighting the lack of established guidelines for vitamin K supplementation in the general population 3, 4, 5