Using Rosuvastatin in Patients with Abnormal Liver Function Tests Due to Fatty Liver Disease

Assessment of Liver Disease Severity

Before prescribing rosuvastatin, determine the likelihood of liver fibrosis using non-invasive methods such as FIB-4 or NAFLD fibrosis score, with low risk of advanced fibrosis for patients with FIB-4 scores <1.3 or NAFLD fibrosis scores ≤1.455, according to the American Association for the Study of Liver Diseases 1

The two most common causes of fatty liver disease are non-alcoholic fatty liver disease (related to insulin resistance and metabolic syndrome) and alcohol-induced steatosis/steatohepatitis, as stated by the American College of Radiology 2
Non-alcoholic fatty liver disease is the most common liver disease in developed countries, with a prevalence of 20-30% in the general population, increasing to 70% with obesity and 90% with diabetes mellitus, according to the American College of Radiology 3