Medications That Can Cause Kidney Injury

Medications with High Risk of Kidney Injury

The combination product oxycodone-acetaminophen contains an NSAID component that can cause kidney dysfunction and direct kidney injury through altered intraglomerular hemodynamics and direct tubular toxicity, according to the Kidney International guidelines 1, 3
NSAIDs, such as those in oxycodone-acetaminophen, impact kidney function through systemic hypotension and intraglomerular hemodynamic effects, as recommended by the Kidney International guidelines 3
Hydralazine may contribute to hypotension-mediated kidney dysfunction, especially when combined with other antihypertensives, as stated by the Kidney International guidelines 3

Advanced age is a risk factor for drug-induced kidney injury, as noted by the Kidney International guidelines 2
Potential dehydration, such as with multiple laxatives prescribed, increases the risk of kidney injury, according to the Kidney International guidelines 3
Concomitant use of multiple potentially nephrotoxic drugs increases the risk of kidney injury, as recommended by the Kidney International guidelines 3
Possible underlying chronic kidney disease is a risk factor for drug-induced kidney injury, as stated by the Kidney International guidelines 2

Regular monitoring of kidney function with serum creatinine and BUN measurements is recommended, as suggested by the Kidney International guidelines 2
Ensuring adequate hydration, especially with laxative use, can help prevent kidney injury, according to the Kidney International guidelines 3
Watching for early signs of kidney injury, such as decreased urine output, edema, or rising creatinine, is crucial, as recommended by the Kidney International guidelines 2

The "triple whammy" effect, where NSAIDs are combined with diuretics and ACE inhibitors/ARBs, increases the risk of kidney injury, as noted by the Kidney International guidelines 3
The risk of kidney injury increases with duration of therapy and total drug burden, according to the Kidney International guidelines 3
Drug-induced kidney injury can occur through various mechanisms, including direct tubular toxicity, altered hemodynamics, immune-mediated injury, and crystal nephropathy, as stated by the Kidney International guidelines 1, 2