Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/28/2025

ACLS Ventricular Fibrillation Preparation

Equipment Preparation

  • The American Heart Association recommends ensuring defibrillator is immediately available and functional with appropriate energy settings (biphasic: manufacturer recommendation 120-200J; monophasic: 360J) 1
  • Prepare airway management equipment including bag-mask device with HEPA filter, especially for suspected COVID-19 patients, as recommended by the American Heart Association 3
  • The American Heart Association suggests preparing supraglottic airway devices or endotracheal intubation equipment, and waveform capnography for confirming and monitoring advanced airway placement 1, 2
  • Establish suction devices with large-bore, non-kinking suction tubing and semi-rigid pharyngeal tips, and adequate vacuum (>40 L/min airflow, >300 mmHg vacuum when clamped), as recommended by the American Heart Association 4
  • Prepare IV/IO access equipment for medication administration, as suggested by the American Heart Association 5

Medication Preparation

  • The American Heart Association recommends preparing amiodarone for refractory VF/pVT, with a first dose of 300 mg bolus IV/IO, and a second dose of 150 mg IV/IO 5
  • Prepare lidocaine for refractory VF/pVT, with a first dose of 1-1.5 mg/kg IV/IO, and a second dose of 0.5-0.75 mg/kg IV/IO, as suggested by the American Heart Association 5
  • Prepare epinephrine 1 mg IV/IO, to be administered every 3-5 minutes, as recommended by the American Heart Association 2

Team Preparation

  • Assign clear roles to team members, including compressor(s) to perform high-quality chest compressions, and airway manager to secure and maintain the airway, as recommended by the American Heart Association 1
  • Plan for compressor rotation every 2 minutes to minimize fatigue and maintain high-quality compressions, as suggested by the American Heart Association 1, 5
  • Ensure all team members wear appropriate PPE, especially when aerosol-generating procedures are anticipated, as recommended by the American Heart Association 3

CPR Quality Monitoring Preparation

  • Set up quantitative waveform capnography to monitor CPR quality, with a target PETCO2 <10 mmHg, as recommended by the American Heart Association 1, 5
  • Consider intra-arterial pressure monitoring if available, with a target relaxation phase pressure <20 mmHg, as suggested by the American Heart Association 1, 5
  • Prepare for continuous assessment of compression rate (100-120/min), compression depth (at least 2 inches/5 cm), complete chest recoil, and minimal interruptions in compressions, as recommended by the American Heart Association 1, 5

Algorithm Review

  • Review VF/pVT algorithm with team, including immediate recognition of cardiac arrest, early CPR with minimal interruptions, rhythm check and defibrillation as soon as possible, and consideration of antiarrhythmic drugs after 2-3 shocks, as recommended by the American Heart Association 1, 2, 5

Special Considerations

  • For pregnant patients, prepare for lateral uterine displacement to relieve aortocaval compression, as recommended by the American Heart Association 3
  • For suspected COVID-19 patients, ensure appropriate PPE and HEPA filters on ventilation equipment, as suggested by the American Heart Association 3
  • Consider ECPR (extracorporeal CPR) preparation for select patients when conventional CPR is failing, as recommended by the American Heart Association 6

Common Pitfalls to Avoid

  • Avoid excessive ventilation (maintain 8-10 breaths/minute with advanced airway), as recommended by the American Heart Association 1, 2
  • Minimize interruptions in chest compressions, including during advanced airway placement, as suggested by the American Heart Association 2, 7
  • Avoid delays in defibrillation while preparing medications, as recommended by the American Heart Association 8
  • Don't rely solely on ETCO2 cutoff values for prognostication or termination decisions, as suggested by the American Heart Association 6
  • Prevent prolonged pulse checks; if pulse is not definitely felt within 10 seconds, resume CPR, as recommended by the American Heart Association 3

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