Tizanidine Dosing Considerations
Monitoring and Dosing Recommendations
- The American Geriatrics Society recommends close surveillance for somnolence/drowsiness and dizziness as indicators of potential overdose in patients with renal impairment 1
- Standard dosing for patients with CrCl ≥25 mL/min is 2 mg TID, with standard titration strategy 1
Pharmacokinetic Considerations
- No cited facts are available for this section
Practical Dosing Algorithm
| Renal Function | Starting Approach | Titration Strategy | |
|---|---|---|---|
| CrCl ≥25 mL/min | Standard dosing (2 mg TID) | Standard titration | [1] |