Maximum Dose of S-Amlodipine for Hypertension

Standard Adult Dosing

• The maximum dose of amlodipine for adults is 10 mg once daily, as the maximum dose is acceptable under normal circumstances 1

Pediatric Dosing Limits

• For children aged 6-17 years, the maximum dose of amlodipine is 5 mg once daily, and doses exceeding this have not been studied and are not recommended 2

Special Clinical Context: Pulmonary Hypertension

• The European Society of Cardiology notes that for idiopathic pulmonary arterial hypertension in carefully selected vasoreactive patients, doses up to 20 mg daily may be used, though this is off-label 3, 2
• This higher dosing is reserved exclusively for IPAH patients who demonstrate positive acute vasodilator response during right heart catheterization, and only a small subset of IPAH patients meet criteria for this approach 3, 2

Drug Interaction Consideration

• When coadministered with simvastatin or lovastatin, amlodipine doses should not exceed 20 mg daily due to increased statin exposure and myopathy risk 2

Pharmacokinetic Rationale

• Amlodipine's long half-life supports true once-daily dosing with sustained 24-hour blood pressure control, with a half-life of 30-50 hours 2, 1